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The Sound of Evolution
Carboprost tromethamine
Mechanism of action:
Carboprost tromethamine is an analog of prostaglandin F2alpha (PGF2alpha). Carboprost tromethamine binds to prostaglandin F receptors on uterine smooth muscle cells and activates the phospholipase Cbeta-IP3-Ca2+ pathway, increasing cytosolic Ca2+ concentration and causing strong uterine smooth muscle contraction.
Reference(s):
1. Hay A et al. (2010). Labour is associated with decreased expression of the PGF2alpha receptor (PTGFR) and a novel PTGFR splice variant in human myometrium but not decidua. Mol Hum Reprod.
2. Zhou Y et al. (2024). TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res.
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