The Sound of Evolution
Carteolol
Mechanism of action:
Carteolol is a non-selective beta-adrenergic blocker. In the eye, carteolol blocks beta2 receptors in the ciliary body, thereby inhibiting aqueous humor production, and also blocks beta1 receptors, reducing beta receptor-mediated signaling involved in aqueous humor formation. In the cardiovascular system, it blocks cardiac beta1 receptors, lowering heart rate and contractility, which reduces blood pressure and myocardial oxygen demand. It also blocks beta2 receptors in blood vessels and bronchi, causing mild bronchoconstriction.
Reference(s):
1. El-Kamel A et al. (2006). Environmentally responsive ophthalmic gel formulation of carteolol hydrochloride. Drug Deliv.
2. Kuwahara K et al. (2005). Carteolol hydrochloride protects human corneal epithelial cells from UVB-induced damage in vitro. Cornea.
3. Trinquand C et al. (2003). Efficacy and safety of long-acting carteolol 1% once daily: a double-masked, randomized study. J Fr Ophtalmol.