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The Sound of Evolution
Cefaclor
Mechanism of action:
Cefaclor is a second-generation oral cephalosporin antibiotic. The beta-lactam ring of cefaclor binds to bacterial penicillin-binding proteins (PBPs) and inhibits their transpeptidase activity, preventing cross-linking of peptidoglycan chains. As a result, the cell wall structure becomes fragile, and the bacteria undergo lysis and die because of osmotic pressure.
Reference(s):
1. Hebert AA et al. (1991). Serum sickness-like reactions from cefaclor in children. J Am Acad Dermatol.
2. Parra FM et al. (1992). Serum sickness-like syndrome associated with cefaclor therapy. Allergy.
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