The Sound of Evolution
Cefepime
Mechanism of action:
Cefepime is a fourth-generation cephalosporin antibiotic. The β-lactam ring of Cefepime can bind to bacterial penicillin-binding proteins (PBPs), inhibiting their transpeptidase activity and preventing peptidoglycan chains from cross-linking. As a result, the bacterial cell wall becomes structurally weak, and the bacterium eventually undergoes lysis and dies due to osmotic pressure.
Reference(s):
1. Chapman TM et al. (2003). Cefepime: a review of its use in the management of hospitalized patients with pneumonia. Am J Respir Med.
2. Barbhaiya RH et al. (1991). Disposition of the cephalosporin cefepime in normal and renally impaired subjects. Drug Metab Dispos.
3. Ortega AJ et al. (2021). Cefepime-induced encephalopathy in a high-risk patient with renal insufficiency and cirrhosis. Cureus.