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The Sound of Evolution
Cefixime
Mechanism of action:
Cefixime is a third-generation oral cephalosporin antibiotic. The β-lactam ring of Cefixime can bind to bacterial penicillin-binding proteins (PBPs), inhibiting their transpeptidase activity and preventing peptidoglycan chains from cross-linking. As a result, the bacterial cell wall becomes structurally weak, and the bacterium eventually undergoes lysis and dies due to osmotic pressure.
Reference(s):
1. McMillan A et al. (2007). The treatment of pharyngeal gonorrhoea with a single oral dose of cefixime. Int J STD AIDS.
2. Adam D et al. (1995). 5-day cefixime therapy for bacterial pharyngitis and/or tonsillitis: comparison with 10-day penicillin V therapy. Infection.
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