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The Sound of Evolution
Cefoperazone
Mechanism of action:
Cefoperazone is a third-generation cephalosporin antibiotic. The β-lactam ring of Cefoperazone can bind to bacterial penicillin-binding proteins (PBPs), inhibiting their transpeptidase activity and preventing peptidoglycan chains from cross-linking. As a result, the bacterial cell wall becomes structurally weak, and the bacterium eventually undergoes lysis and dies due to osmotic pressure.
Reference(s):
1. Jones RN et al. (1983). Cefoperazone: a review of its antimicrobial spectrum, beta-lactamase stability, enzyme inhibition, and other in vitro characteristics. Rev Infect Dis.
2. TITCK. (n.d.). Product Information: Cefobid (cefoperazone sodium) for intramuscular/intravenous injection.
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