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Cefotetan


Mechanism of action:

Cefotetan is a second-generation cephalosporin antibiotic. The β-lactam ring of Cefotetan can bind to bacterial penicillin-binding proteins (PBPs), inhibiting their transpeptidase activity and preventing peptidoglycan chains from cross-linking. As a result, the bacterial cell wall becomes structurally weak, and the bacterium eventually undergoes lysis and dies due to osmotic pressure.

Reference(s):

Nolan RD et al. (1983). The interactions of [14C]cefotetan with penicillin binding proteins of a wide variety of Gram-positive and gram-negative species. J Antimicrob Chemother.

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