top of page
< Back

Cefpodoxime


Mechanism of action:

Cefpodoxime is a third-generation oral cephalosporin antibiotic. The β-lactam ring of Cefpodoxime can bind to bacterial penicillin-binding proteins (PBPs), inhibiting their transpeptidase activity and preventing peptidoglycan chains from cross-linking. As a result, the bacterial cell wall becomes structurally weak, and the bacterium eventually undergoes lysis and dies due to osmotic pressure.

Reference(s):

Boaretti M et al. (1991). In vitro activity, beta-lactamase stability and PBP affinity of RU 51,746-2, the active metabolite of the new orally absorbed cephalosporin ester, RU 51807. J Chemother.

bottom of page