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Cefpodoxime

Mechanism of action:
Cefpodoxime is a third-generation oral cephalosporin antibiotic. The β-lactam ring of Cefpodoxime can bind to bacterial penicillin-binding proteins (PBPs), inhibiting their transpeptidase activity and preventing peptidoglycan chains from cross-linking. As a result, the bacterial cell wall becomes structurally weak, and the bacterium eventually undergoes lysis and dies due to osmotic pressure.
Reference(s):
Boaretti M et al. (1991). In vitro activity, beta-lactamase stability and PBP affinity of RU 51,746-2, the active metabolite of the new orally absorbed cephalosporin ester, RU 51807. J Chemother.
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