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The Sound of Evolution
Ceftaroline
Mechanism of action:
Ceftaroline is a fifth-generation cephalosporin antibiotic. The β-lactam ring of Ceftaroline can bind to bacterial penicillin-binding proteins (PBPs), inhibiting their transpeptidase activity and preventing peptidoglycan chains from cross-linking. As a result, the bacterial cell wall becomes structurally weak, and the bacterium eventually undergoes lysis and dies due to osmotic pressure.
Reference(s):
1. Steed ME et al. (2010). Ceftaroline: a new cephalosporin with activity against resistant gram-positive pathogens. Pharmacotherapy.
2. Kollef MH et al. (2009). New antimicrobial agents for methicillin-resistant Staphylococcus aureus. Crit Care Resusc.
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