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The Sound of Evolution
Ceftazidime
Mechanism of action:
Ceftazidime is a third-generation cephalosporin antibiotic. The β-lactam ring of Ceftazidime can bind to bacterial penicillin-binding proteins (PBPs), inhibiting their transpeptidase activity and preventing peptidoglycan chains from cross-linking. As a result, the bacterial cell wall becomes structurally weak, and the bacterium eventually undergoes lysis and dies due to osmotic pressure.
Reference(s):
1. Fisher JF et al. (2020). Constructing and deconstructing the bacterial cell wall. Protein Sci.
2. Bush K et al. (2016). Beta-lactams and beta-lactamase inhibitors: An overview. Cold Spring Harb Perspect Med.
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