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Ceftibuten


Mechanism of action:

Ceftibuten is a third-generation oral cephalosporin antibiotic. The β-lactam ring of Ceftibuten can bind to bacterial penicillin-binding proteins (PBPs), inhibiting their transpeptidase activity and preventing peptidoglycan chains from cross-linking. As a result, the bacterial cell wall becomes structurally weak, and the bacterium eventually undergoes lysis and dies due to osmotic pressure.

Reference(s):

Wise R et al. (1990). Ceftibuten—in vitro activity against respiratory pathogens, beta-lactamase stability and mechanism of action. J Antimicrob Chemother.

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