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Ceftizoxime


Mechanism of action:

Ceftizoxime is a third-generation cephalosporin antibiotic. The β-lactam ring of Ceftizoxime can bind to bacterial penicillin-binding proteins (PBPs), inhibiting their transpeptidase activity and preventing peptidoglycan chains from cross-linking. As a result, the bacterial cell wall becomes structurally weak, and the bacterium eventually undergoes lysis and dies due to osmotic pressure.

Reference(s):

Richards DM et al. (1985). Ceftizoxime: A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs.

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