The Sound of Evolution
Ceftobiprole
Mechanism of action:
Ceftobiprole is a fifth-generation cephalosporin antibiotic. The β-lactam ring of Ceftobiprole can bind to bacterial penicillin-binding proteins (PBPs), inhibiting their transpeptidase activity and preventing peptidoglycan chains from cross-linking. As a result, the bacterial cell wall becomes structurally weak, and the bacterium eventually undergoes lysis and dies due to osmotic pressure.
Reference(s):
1. Davies TA et al. (2007). Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. Antimicrob Agents Chemother.
2. Noel GJ et al. (2007). Clinical profile of ceftobiprole, a novel beta-lactam antibiotic. Clin Microbiol Infect.