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Ceftriaxone


Mechanism of action:

Ceftriaxone is a third-generation cephalosporin antibiotic. The β-lactam ring of Ceftriaxone can bind to bacterial penicillin-binding proteins (PBPs), inhibiting their transpeptidase activity and preventing peptidoglycan chains from cross-linking. As a result, the bacterial cell wall becomes structurally weak, and the bacterium eventually undergoes lysis and dies due to osmotic pressure.

Reference(s):

1. Richards DM et al. (1984). Ceftriaxone: A review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 


2. Park HZ et al. (1991). Ceftriaxone-associated gallbladder sludge: Identification of calcium-ceftriaxone salt as a major component of gallbladder precipitate. Gastroenterology.

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