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The Sound of Evolution
Cetirizine
Mechanism of action:
Cetirizine is a second-generation H₁ receptor antagonist. Cetirizine binds to H₁ receptors in peripheral tissues, stabilizing them in an inactive state and blocking the action of histamine. This suppresses vasodilation and plasma leakage, and reduces neurogenic itching and allergic responses.
Reference(s):
1. Portnoy JM et al. (2004). Review of cetirizine hydrochloride for the treatment of allergic disorders. Expert Opin Pharmacother.
2. Zhang L et al. (2013). The clinical use of cetirizine in the treatment of allergic rhinitis. Pharmacology.
3. Wheatley LM et al. (2015). Clinical practice: Allergic rhinitis. N Engl J Med.
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