top of page
The Sound of Evolution
Chloramphenicol
Mechanism of action:
Chloramphenicol binds to the 23S rRNA of the 50S subunit of the bacterial ribosome and blocks peptidyl transferase activity. This also prevents peptide bond formation between amino acids, thereby halting protein synthesis.
Reference(s):
1. Bhutta ZA et al. (1992). Chloramphenicol clearance in typhoid fever: implications for therapy. Indian J Pediatr.
2. Wali SS et al. (1979). Single injection treatment of meningococcal meningitis: Long-acting chloramphenicol. Trans R Soc Trop Med Hyg.
3. Puddicombe JB et al. (1984). A field trial of a single intramuscular injection of long-acting chloramphenicol in the treatment of meningococcal meningitis. Trans R Soc Trop Med Hyg.
bottom of page