The Sound of Evolution
Chlordiazepoxide
Mechanism of action:
Chlordiazepoxide is a long-acting benzodiazepine derivative. Chlordiazepoxide binds to the benzodiazepine binding site on the GABA_A receptor and enhances the efficiency of GABA_A receptor function. This increases the frequency of chloride (Cl⁻) channel opening after GABA binds, causing hyperpolarization of neuronal membranes and reducing neuronal excitability. Through this mechanism, it produces sedative, anxiolytic, muscle relaxant, and anticonvulsant effects.
Reference(s):
1. Skerritt JH et al. (1983). Enhancement of GABA binding by benzodiazepines and related anxiolytics. Eur J Pharmacol.
2. Oishi R et al. (1986). Diazepam-induced decrease in histamine turnover in mouse brain. Eur J Pharmacol.
3. Earley JV et al. (1979). Quinazolines and 1,4-benzodiazepines: Haptens useful in benzodiazepine immunoassay development. J Pharm Sci.