top of page
< Back

Chlormezanone


Mechanism of action:

Chlormezanone is a centrally acting muscle relaxant. Its exact molecular mechanism has not been fully clarified, but it may act on the spinal reflex arc and the reticular formation, suppressing polysynaptic reflexes and reducing skeletal muscle tone. Some studies also suggest that chlormezanone may enhance GABAergic inhibitory neurotransmission, contributing to its sedative and anxiolytic effects.

Reference(s):

1. Wollina U et al. (2005). Investigations of interactions of chlormezanone racemate and its enantiomers on human keratinocytes and human leucocytes in vitro. Skin Pharmacol Physiol. 


2. Seeling A et al. (2000). Important pharmaceutical-chemical characteristics of the central muscle relaxant chlormezanone. Pharmazie. 


3. Oelschlager H et al. (1998). Cleavage and biotransformation of the central muscle relaxant chlormezanone. Pharmazie.

bottom of page