Chlorpromazine

Chlorpromazine is a first-generation dopamine D₂ receptor antagonist. Chlorpromazine antagonizes dopamine D₂ receptors. Inhibition of D₂ receptors in the mesolimbic pathway can reduce hallucinations and delusions. Inhibition of D₂ receptors in the mesocortical pathway may affect certain cognitive and emotional or motivational functions. Inhibition of D₂ receptors in the nigrostriatal pathway suppresses motor control and can cause extrapyramidal symptoms (EPS). Inhibition of D₂ receptors in the tuberoinfundibular pathway can cause hyperprolactinemia. Therefore, chlorpromazine produces antipsychotic and antiemetic effects, but these are accompanied by extrapyramidal and endocrine adverse effects.