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The Sound of Evolution
Choriogonadotropin alfa
Mechanism of action:
Choriogonadotropin alfa is recombinant human chorionic gonadotropin (rhCG) and can mimic the action of luteinizing hormone (LH). In ovarian granulosa cells and theca cells, choriogonadotropin alfa binds to the LH/CG receptor and activates the same signaling pathways triggered by luteinizing hormone. This stimulates adenylyl cyclase, increases cAMP levels, and promotes follicular maturation, ovulation, corpus luteum formation, and increased progesterone secretion.
Reference(s):
1. Kayisli UA et al. (2003). Human chorionic gonadotropin contributes to maternal immunotolerance and endometrial apoptosis by regulating Fas–Fas ligand system. J Immunol.
2. Askling J et al. (1999). Sickness in pregnancy and sex of child. Lancet.
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