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The Sound of Evolution
Cinoxacin
Mechanism of action:
Cinoxacin is a first-generation quinolone antibiotic. Cinoxacin binds to the DNA gyrase-DNA complex and prevents the re-ligation of cleaved DNA generated by DNA gyrase. This leads to the accumulation of double-stranded DNA breaks, cessation of DNA replication and transcription, and ultimately bacterial death.
Reference(s):
1. Jariyawat S et al. (1999). The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther.
2. Drlica K et al. (1997). DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev.
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