The Sound of Evolution
Citalopram
Mechanism of action:
Citalopram is a selective serotonin reuptake inhibitor. In central nervous system synapses, serotonin (5-hydroxytryptamine, 5-HT) released into the synaptic cleft is normally taken back up into the presynaptic neuron by the serotonin transporter after a period of time for reuse. Citalopram inhibits the function of the serotonin transporter, preventing the concentration of serotonin in the synaptic cleft from falling. This prolongs the duration of 5-HT action on its receptors and can reduce symptoms of anxiety and depression.
Reference(s):
1. Sindrup SH et al. (1992). The selective serotonin reuptake inhibitor citalopram relieves the symptoms of diabetic neuropathy. Clin Pharmacol Ther.
2. Atmaca M et al. (2002). The efficacy of citalopram in the treatment of premature ejaculation: a placebo-controlled study. Int J Impot Res.
3. Andersen G et al. (1993). Citalopram for post-stroke pathological crying. Lancet.