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The Sound of Evolution
Clarithromycin
Mechanism of action:
Clarithromycin is a macrolide antibiotic and a derivative of erythromycin. Clarithromycin reversibly binds to the 23S rRNA of the bacterial 50S ribosomal subunit and blocks the translocation step during peptide chain elongation, thereby inhibiting protein synthesis.
Reference(s):
1. Malhotra-Kumar S et al. (2007). Effect of azithromycin and clarithromycin therapy on pharyngeal carriage of macrolide-resistant streptococci in healthy volunteers: a randomised, double-blind, placebo-controlled study. Lancet.
2. Zuckerman JM et al. (2009). Macrolides, ketolides, and glycylcyclines: azithromycin, clarithromycin, telithromycin, tigecycline. Infect Dis Clin North Am.
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