top of page
< Back

Clevidipine


Mechanism of action:

Clevidipine is a short-acting dihydropyridine calcium channel blocker. Clevidipine acts mainly on L-type calcium channels in vascular smooth muscle cells, blocking the entry of calcium ions from outside the cell into the cytoplasm. This reduces smooth muscle contraction and causes vasodilation.

Reference(s):

1. Zhang JG et al. (2006). Human cytochrome P450 induction and inhibition potential of clevidipine and its primary metabolite h152/81. Drug Metab Dispos. 


2. Nordlander M et al. (2004). Pharmacodynamic, pharmacokinetic and clinical effects of clevidipine, an ultrashort-acting calcium antagonist for rapid blood pressure control. Cardiovasc Drug Rev. 


3. Wang QD et al. (2002). Time-dependent cardioprotection with calcium antagonism and experimental studies with clevidipine in ischemic-reperfused pig hearts: part I. J Cardiovasc Pharmacol.

bottom of page