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The Sound of Evolution
Clindamycin
Mechanism of action:
Clindamycin is a lincosamide antibiotic. Clindamycin reversibly binds to the bacterial 50S ribosomal subunit, particularly to the peptidyl transferase center of 23S rRNA. This prevents peptide chain elongation and interferes with translocation, thereby blocking protein synthesis and inhibiting bacterial growth.
Reference(s):
1. Daum RS et al. (2007). Clinical practice: Skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus. N Engl J Med.
2. Klempner MS et al. (1981). Clindamycin uptake by human neutrophils. J Infect Dis.
3. Lamont RF et al. (2005). Can antibiotics prevent preterm birth—the pro and con debate. BJOG.
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