The Sound of Evolution
Clobazam
Mechanism of action:
Clobazam is a benzodiazepine derivative. Its main mechanism of action is to enhance the inhibitory transmission mediated by GABA_A receptors in the central nervous system. Clobazam binds to the benzodiazepine-binding site on the GABA_A receptor and increases the receptor's affinity for GABA. After GABA binding is enhanced, clobazam increases the frequency of chloride channel opening, leading to greater chloride influx into neurons. This causes hyperpolarization of the cell membrane, lowers the probability of neuronal action potential transmission, and ultimately produces anticonvulsant, sedative, and anxiolytic effects.
Reference(s):
1. Freche C et al. (1975). Study of an anxiolytic, clobazam, in otorhinolaryngology in psychosomatic pharyngeal manifestations. Sem Hop Ther.
2. Canadian Clobazam Cooperative Group. (1991). Clobazam in treatment of refractory epilepsy: the Canadian experience. A retrospective study. Epilepsia.
3. Wildin JD et al. (1990). Respiratory and sedative effects of clobazam and clonazepam in volunteers. Br J Clin Pharmacol.