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The Sound of Evolution
Clonazepam
Mechanism of action:
Clonazepam is a benzodiazepine derivative. Clonazepam binds to the benzodiazepine-binding site on the GABA_A receptor and enhances the receptor's affinity for GABA. Once GABA binding is increased, the frequency of chloride channel opening rises, leading to chloride influx into neurons. This causes membrane hyperpolarization and reduces the generation of action potentials.
Reference(s):
1. Dreifuss FE et al. (1975). Serum clonazepam concentrations in children with absence seizures. Neurology.
2. Robertson MD et al. (1995). Postmortem drug metabolism by bacteria. J Forensic Sci.
3. Rosen GM et al. (1988). Synthesis of spin traps specific for hydroxyl radical. J Med Chem.
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