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The Sound of Evolution
Cloxacillin
Mechanism of action:
Cloxacillin is a β-lactam antibiotic. The β-lactam ring of cloxacillin binds to bacterial penicillin-binding proteins (PBPs) and inhibits their transpeptidase activity, preventing cross-linking of peptidoglycan chains. This weakens the cell wall structure, and the bacteria eventually rupture and die because of osmotic pressure.
Reference(s):
1. Lalanne S et al. (2020). Differential interactions of the beta-lactam cloxacillin with human renal organic anion transporters (OATs). Fundam Clin Pharmacol.
2. Thijssen HH et al. (1976). Active metabolites of isoxazolylpenicillins in humans. Antimicrob Agents Chemother.
3. Bratlid D et al. (1976). Displacement of albumin-bound antimicrobial agents by bilirubin. Pharmacology.
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