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Cyclobenzaprine


Mechanism of action:

Cyclobenzaprine is a centrally acting skeletal muscle relaxant and belongs to the tricyclic compounds. Its mechanism of action is not fully understood. It mainly acts on the reticular formation of the brainstem and spinal cord, where it reduces the activity of spinal α-motor neurons by inhibiting polysynaptic reflexes, thereby decreasing skeletal muscle tone.

Reference(s):

1. Wang RW et al. (1996). Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine. Drug Metab Dispos. 


2. Lu D et al. (2017). N-glucuronidation catalyzed by UGT1A4 and UGT2B10 in human liver microsomes: Assay optimization and substrate identification. J Pharm Biomed Anal. 


3. Kobayashi H et al. (1996). Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems. Eur J Pharmacol.

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