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The Sound of Evolution
Dabigatran
Mechanism of action:
Dabigatran is a direct thrombin inhibitor. The oral formulation commonly used clinically is its prodrug, dabigatran etexilate, which is hydrolyzed in the body to form dabigatran. Dabigatran inhibits the activity of thrombin, preventing fibrinogen from being converted into fibrin and thereby blocking thrombus formation.
Reference(s):
1. Zhou Y et al. (2024). TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res.
2. Korff M et al. (2020). Acylated 1H-1,2,4-triazol-5-amines targeting human coagulation factor XIIa and thrombin: conventional and microscale synthesis, anticoagulant properties, and mechanism of action. J Med Chem.
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