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The Sound of Evolution
Daclatasvir
Mechanism of action:
Daclatasvir inhibits the function of the hepatitis C virus NS5A protein, thereby blocking the formation and activity of the viral RNA replication complex. Daclatasvir also disrupts the assembly and release of viral particles.
Reference(s):
1. Belema M et al. (2014). Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir. J Med Chem.
2. Guedj J et al. (2013). Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life. Proc Natl Acad Sci U S A.
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