The Sound of Evolution
Dalfopristin
Mechanism of action:
Dalfopristin is a streptogramin antibiotic and is commonly used in combination with quinupristin. Dalfopristin binds to the peptidyl transferase center of the bacterial 50S ribosomal subunit, preventing elongation of the nascent peptide chain. It also alters ribosomal conformation, significantly increasing the binding affinity of quinupristin and thereby inhibiting protein synthesis.
Reference(s):
1. Allington DR et al. (2001). Quinupristin/dalfopristin: a therapeutic review. Clin Ther.
2. Lamb HM et al. (1999). Quinupristin/dalfopristin: a review of its use in the management of serious gram-positive infections. Drugs.
3. Manzella JP et al. (2001). Quinupristin–dalfopristin: a new antibiotic for severe gram-positive infections. Am Fam Physician.