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The Sound of Evolution
Darifenacin
Mechanism of action:
Darifenacin is an anticholinergic agent and a selective M3 muscarinic receptor antagonist. In the bladder detrusor muscle, when acetylcholine binds to M3 receptors, it promotes smooth muscle contraction and triggers the micturition reflex. Darifenacin antagonizes M3 receptors, inhibiting the action of acetylcholine and reducing involuntary contractions of the detrusor muscle.
Reference(s):
1. Bharucha AE et al. (2010). Comparison of selective M3 and nonselective muscarinic receptor antagonists on gastrointestinal transit and bowel habits in humans. Am J Physiol Gastrointest Liver Physiol.
2. Jha S et al. (2006). Treatment of overactive bladder in the aging population: focus on darifenacin. Clin Interv Aging.
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