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The Sound of Evolution
Darunavir
Mechanism of action:
Darunavir is an HIV-1 protease inhibitor. Darunavir binds with high affinity to the active site of HIV-1 protease, preventing the enzyme from cleaving the Gag-Pol polyprotein precursor into functional proteins. As a result, newly produced viral particles remain immature and noninfectious.
Reference(s):
1. Back D et al. (2008). Darunavir: pharmacokinetics and drug interactions. Antivir Ther.
2. Tremblay CL et al. (2008). Combating HIV resistance – focus on darunavir. Ther Clin Risk Manag.
3. Koh Y et al. (2007). Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization. J Biol Chem.
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