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Dasabuvir


Mechanism of action:

Dasabuvir is a non-nucleoside NS5B RNA polymerase inhibitor. The NS5B polymerase of hepatitis C virus is responsible for synthesizing new viral RNA using viral RNA as a template. Dasabuvir binds to an allosteric site in the palm domain of NS5B, altering its conformation and blocking RNA chain elongation. This inhibits viral RNA synthesis and prevents viral replication.

Reference(s):

1. Gentile I et al. (2014). Dasabuvir: A Non-Nucleoside Inhibitor of NS5B for the Treatment of Hepatitis C Virus Infection. Rev Recent Clin Trials. 


2. Trivella JP et al. (2015). Dasabuvir: a new direct antiviral agent for the treatment of hepatitis C. Expert Opin Pharmacother. 


3. Mantry PS et al. (2016). Dasabuvir (ABT333) for the treatment of chronic HCV genotype I: a new face of cure, an expert review. Expert Rev Anti Infect Ther.

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