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The Sound of Evolution
Degarelix
Mechanism of action:
Degarelix is a gonadotropin-releasing hormone antagonist (GnRH antagonist). Degarelix selectively binds to and blocks GnRH receptors in the anterior pituitary, preventing activation by gonadotropin-releasing hormone (GnRH). This antagonism suppresses pituitary secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which subsequently lowers testosterone production by Leydig cells in the testes.
Reference(s):
1. Steinberg M et al. (2009). Degarelix: a gonadotropin-releasing hormone antagonist for the management of prostate cancer. Clin Ther.
2. Persson BE et al. (2009). Degarelix: a new approach for the treatment of prostate cancer. Neuroendocrinology.
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