The Sound of Evolution
Delavirdine
Mechanism of action:
Delavirdine is a non-nucleoside reverse transcriptase inhibitor. Delavirdine binds to a hydrophobic allosteric site on the HIV-1 reverse transcriptase enzyme, altering the protein's conformation and reducing enzymatic activity, thereby blocking reverse transcription of viral RNA into DNA. It is active only against HIV-1.
Reference(s):
1. Geitmann M et al. (2006). Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors. J Med Chem.
2. Xia Q et al. (2007). Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analyses. Protein Sci.
3. Freimuth WW et al. (1996). Delavirdine mesylate, a potent non-nucleoside HIV-1 reverse transcriptase inhibitor. Adv Exp Med Biol.