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Desloratadine


Mechanism of action:

Desloratadine is a second-generation H₁ receptor antagonist and a piperidine derivative. After histamine is released, it binds to H₁ receptors and triggers allergic responses such as vasodilation, increased capillary permeability, itching, and mucus secretion. Desloratadine competitively blocks this receptor, thereby preventing histamine-induced inflammation and allergy-related symptoms.

Reference(s):

1. Mann RD et al. (2000). Sedation with “non-sedating” antihistamines: four prescription-event monitoring studies in general practice. BMJ. 


2. Glass DJ et al. (2003). Assessing satisfaction with desloratadine and fexofenadine in allergy patients who report dissatisfaction with loratadine. BMC Fam Pract.

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