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The Sound of Evolution
Dexlansoprazole
Mechanism of action:
Dexlansoprazole is a proton pump inhibitor and a benzimidazole derivative. It is a prodrug that is converted within the acidic secretory canaliculi of gastric parietal cells into its active sulfenamide form. This sulfenamide forms covalent bonds with the H⁺/K⁺-ATPase proton pump, irreversibly inhibiting proton secretion and thereby blocking gastric acid production.
Reference(s):
1. Behm BW et al. (2011). Dexlansoprazole MR for the management of gastroesophageal reflux disease. Expert Rev Gastroenterol Hepatol.
2. Skrzydlo-Radomanska B et al. (2015). Dexlansoprazole – a new-generation proton pump inhibitor. Prz Gastroenterol.
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