The Sound of Evolution
Dibucaine
Mechanism of action:
Dibucaine is an amide derivative. It binds to sodium channel proteins on the inner side of the neuronal cell membrane and inhibits the depolarization phase of the action potential, thereby blocking the generation and conduction of nerve impulses. This results in local loss of sensation (numbness), especially pain and temperature sensation.
Reference(s):
1. Abdel-Ghani NT et al. (2005). Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry. Farmaco.
2. Souto-Padron T et al. (2006). Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi. Parasitol Res.
3. Nounou MM et al. (2005). Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles. Acta Pol Pharm.