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The Sound of Evolution
Diclofenac
Mechanism of action:
Diclofenac is a phenylacetic acid derivative. It inhibits cyclooxygenase (COX), including both COX-1 and COX-2, thereby reducing prostaglandin production and ultimately decreasing prostaglandin-mediated inflammatory signaling and pain sensitization.
Reference(s):
1. Kearney PM et al. (2006). Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ.
2. Solomon DH et al. (2006). Cardiovascular outcomes in new users of coxibs and nonsteroidal antiinflammatory drugs: high-risk subgroups and time course of risk. Arthritis Rheum.
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