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The Sound of Evolution
Didanosine
Mechanism of action:
Didanosine is a nucleoside reverse transcriptase inhibitor and a deoxyinosine derivative. Within cells, it is metabolized into dideoxyadenosine triphosphate (ddATP), which competes with dATP for incorporation by HIV reverse transcriptase. However, because didanosine lacks a 3'-OH group, viral reverse transcription is terminated.
Reference(s):
1. Faulds D et al. (1992). Didanosine. A review of its antiviral activity, pharmacokinetic properties and therapeutic potential in human immunodeficiency virus infection. Drugs.
2. Zhou Y et al. (2024). TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res.
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