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The Sound of Evolution
Diflunisal
Mechanism of action:
Diflunisal is a salicylic acid derivative. It reversibly inhibits cyclooxygenase, including the activities of COX-1 and COX-2, thereby blocking the conversion of arachidonic acid into prostaglandins and thromboxanes. This in turn reduces prostaglandin-mediated inflammation, pain, and fever-related responses.
Reference(s):
1. Cappon GD et al. (2003). Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure. Birth Defects Res B Dev Reprod Toxicol.
2. Jeske AH et al. (1999). COX-2 inhibitors and dental pain control. J Gt Houst Dent Soc.
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