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Dinoprostone


Mechanism of action:

Dinoprostone is a synthetic derivative of prostaglandin E2 and functions as a cervical ripening and uterotonic agent. It binds to prostaglandin E receptors on the surface of cervical and uterine smooth muscle cells, especially EP2, EP3, and EP4. It then increases the expression of collagenase and matrix metalloproteinases, promoting the breakdown of collagen fibers in the cervical stroma. It also increases the content of glycosaminoglycans and water, making cervical tissue softer, more relaxed, and more distensible.

Reference(s):

1. Baryawno N et al. (2008). Tumor-growth-promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets. Neuro Oncol. 


2. Tamiji J et al. (2010). Prostaglandin E(2) and misoprostol induce neurite retraction in Neuro-2a cells. Biochem Biophys Res Commun.

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