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The Sound of Evolution
Dirithromycin
Mechanism of action:
Dirithromycin is a macrolide antibiotic. It is converted in the body into the active metabolite erythromycyclamine. This metabolite binds to the 50S subunit of the bacterial ribosome and blocks translocation during peptide chain elongation, thereby interrupting protein synthesis.
Reference(s):
1. Brogden RN et al. (1994). Dirithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy. Drugs.
2. Wintermeyer SM et al. (1996). Dirithromycin: a new macrolide. Ann Pharmacother.
3. Sides GD et al. (1993). Pharmacokinetics of dirithromycin. J Antimicrob Chemother.
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