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The Sound of Evolution
Divalproex
Mechanism of action:
Divalproex is a valproic acid derivative. It inhibits GABA transaminase and succinic semialdehyde dehydrogenase, reducing the breakdown of GABA and increasing its concentration. It may also promote GABA synthesis. The result is enhanced inhibitory neurotransmission and a reduced tendency toward excessive neuronal excitation.
Reference(s):
1. Rosenberg G et al. (2007). The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees? Cell Mol Life Sci.
2. Lehrman G et al. (2005). Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet.
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