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Dofetilide


Mechanism of action:

Dofetilide is a selective potassium channel blocker. It highly selectively inhibits the hERG potassium channel, the human ether-a-go-go-related potassium channel, which is responsible for the rapid delayed rectifier potassium current, IKr, during cardiac repolarization. When IKr is inhibited by dofetilide, myocardial repolarization is delayed, leading to prolongation of the action potential duration and the QT interval.

Reference(s):

1. Lenz TL et al. (2000). Dofetilide, a new class III antiarrhythmic agent. Pharmacotherapy. 


2. Lenz TL et al. (2000). Dofetilide: A new antiarrhythmic agent approved for conversion and/or maintenance of atrial fibrillation/atrial flutter. Drugs Today (Barc).

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