top of page
The Sound of Evolution
Donepezil
Mechanism of action:
Donepezil is a centrally acting acetylcholinesterase inhibitor. Donepezil reversibly inhibits acetylcholinesterase in the central nervous system, preventing the breakdown of acetylcholine within the synaptic cleft. This increases synaptic acetylcholine levels and enhances cholinergic neurotransmission between neurons.
Reference(s):
1. Xiong G et al. (2005). Combination drug therapy for Alzheimer's disease: what is evidence-based, and what is not? Geriatrics.
2. Yesavage JA et al. (2002). Donepezil and flight simulator performance: effects on retention of complex skills. Neurology.
bottom of page