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The Sound of Evolution
Doripenem
Mechanism of action:
Doripenem is a β-lactam antibiotic belonging to the carbapenem class. The β-lactam ring of doripenem binds to bacterial penicillin-binding proteins (PBPs) and inhibits their transpeptidase activity, preventing cross-linking of peptidoglycan chains. This weakens the bacterial cell wall, ultimately leading to osmotic rupture and bacterial death.
Reference(s):
1. Jones RN et al. (2004). Activities of doripenem (S-4661) against drug-resistant clinical pathogens. Antimicrob Agents Chemother.
2. Chahine EB et al. (2010). Doripenem: a new carbapenem antibiotic. Am J Health Syst Pharm.
3. Dedhia HV et al. (2009). Doripenem: position in clinical practice. Expert Rev Anti Infect Ther.
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