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Dorzolamide


Mechanism of action:

Dorzolamide is a carbonic anhydrase inhibitor. Carbonic anhydrase II is present in the epithelial cells of the ciliary body of the eye and catalyzes the formation of bicarbonate (HCO₃⁻), which is an essential component in aqueous humor production. By inhibiting carbonic anhydrase II, dorzolamide reduces aqueous humor secretion and lowers intraocular pressure.

Reference(s):

1. Martens-Lobenhoffer J et al. (2002). Clinical pharmacokinetics of dorzolamide. Clin Pharmacokinet. 


2. Balfour JA et al. (1997). Dorzolamide. A review of its pharmacology and therapeutic potential in the management of glaucoma and ocular hypertension. Drugs Aging. 


3. Arieta C et al. (2002). Dorzolamide versus apraclonidine in the prevention of the intraocular pressure spike after Nd:YAG laser posterior capsulotomy. Curr Eye Res.

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